Biology 370 Immunobiology

Biology 370: Immunobiology

Winter 2002

Phillip Funk, Ph.D., Assistant Professor

Lecture: M,W,F 12:00-1:00

Lab: Th, 2:30-5:30

Teaching Assistant: Jennifer Magnuson

COURSE SUMMARY

LECTURE SCHEDULE
HELPFUL LINKS

COURSE SUMMARY

Course Objectives:

To introduce students to the structural and functional components of the immune system.
To introduce the different types of immune responses and the biological factors that regulate these responses.
To introduce naturally occurring defects in the immune system including hypersensitivities.

Principal Topics Covered:	Approximate %
General Aspects of Immune Responses	10
Structural and Cellular Organizaton of the Immune System	10
Immunogenetics	20
Antigens; Antibodies, and Other Serum Proteins	20
Antibody Production; Antigen-Antibody Interactions	20
Cell-mediated responses; Modulation of Immune Responses	20

Required Textbook: Immunobiology: The Immune System in Health and Disease, 5^th edition, by Janeway, Travers, and Walport (available in bookstore). This is an excellent textbook that I think you will find valuable for its brevity and clarity. A great deal of our discussion will focus on the excellent illustrations in the text.

A number of supplementary materials may be placed on reserve in the library and given as handouts in class. The class website will also have links to material on the World Wide Web that will be helpful in your studies. The course website is http://condor.depaul.edu/~pfunk/bio370/Index.htm I will post my lecture overheads to the website for you. I cannot guarantee that they will be available before I give the lecture. Do not use the website as a substitute for attending lecture.

COURSE EVALUATION	Weight (%)
Exam I	20
Exam II	20
Exam III	30
Laboratory:
Laboratory Reports	15
Laboratory Exam	15

Grading: Laboratory reports are due to the teaching assistant by the next laboratory period after the exercise is completed. Late reports will receive an unsatisfactory grade. Attendance at the laboratory is absolutely required, including possible requirements that you return to the lab on another day to check results. There will be no make up sessions for the laboratory. Lab reports should be complete, orderly, printed documents. You may not turn in lab reports on diskette or by email. All lab reports should be prepared using a word processor or typewriter.

Exams will be a combination of short answer and essay questions. Exams will be held at the times indicated, any exceptions to this must be arranged with me well ahead of time. There will be no make up examinations without adequate reason (e.g. a Doctor's note, accident report) for why the exam was missed in the first place. Whether or not you will be offered a make up exam is entirely at my discretion. Make up exams must be arranged by the College of Liberal Arts and Sciences, there is a fee for this. Since I post my lecture notes to the web I feel free to require a good deal of specificity in the answers I expect on the exams. You will be tested on your ability to unite concepts presented in different lectures and to think analytically about the information presented in class. The essential ability you should acquire as a young scientist is to reason logically from what you know.

Grading will not be based on classroom attendance but the only way to know what I consider important is to attend the lectures!

Statement of Academic Honesty: It is expected that your work in this course will be original, not copies of another student's work. The university dictates strong sanctions against those who copy another's work without citing the original source. This may also apply to students who allow others to copy their work. This sanction may be as severe as an F in the course. Please refer to the student handbook for a more detailed discussion of the university's rules on this matter. In the laboratory portion of this course you will be required to share your data with other students in order to gain a more complete understanding of the experiment. In writing the laboratory report I expect a clear distinction between YOUR results and those obtained by sharing results with others. Science is a collaborative endeavor but it requires acknowledgement of one's collaborators.

Behavior: You should be on time for both lecture and lab. You should behave as you would like an audience to behave if you were speaking. No talking, note passing, horseplay, etc. Turn OFF ALL CELL PHONES AND BEEPERS. In the laboratory it will be necessary to share reagents, equipment, and results with others. You should be courteous and respectful of your fellow students. Inappropriate and rude conduct in the lab will not be tolerated. Smoking, eating, drinking, and applying make-up are absolutely forbidden in the lab. Extraneous conversation should be kept to a minimum.

Tips for success in this course:

1. 1. All my lecture notes will be available via the class web site. I cannot guarantee that these notes will be posted before the lecture is given. Do not use these notes as a substitute for attending class! There is no substitute for attending class, paying attention, and taking good notes. The successful students in my other classes can tell you that the notes on the web are an excellent addition to the lectures but that you will not do well if you rely solely on the website.

2. 2. Read the book! This also applies to the laboratory, read the exercise beforehand. This will help you understand the experiment before you begin and help you make the most efficient use of your time in the lab.

3. 3. Don't think of each lecture as a single, self-contained entity. Immunology is a field of study and its components are interrelated. Part of my teaching philosophy is to get you to understand some of the interrelationships. This will help you to reason from what you do know to what you don't know.

4. 4. Don't be afraid to ask questions. I welcome student's questions before, during, and after lectures.

5. 5. Be aware of your standing in the class and get help if you need it. If you do poorly on the first exam try to figure out what you did wrong, see the TA or me for explanation. Do not presume that you will get a 100 on the next test. If you need to schedule a meeting with me do so; I always try to be available to answer student's concerns.

CONTACTING YOUR INSTUCTOR

You may contact me by email at pfunk@depaul.edu

My office is 243 McGowan Hall on the Lincoln Park Campus.

I will also be available before and after lecture to answer specific questions. If necessary I will establish office hours. I will do my utmost to answer questions in a timely fashion. I sincerely want this course to be a rewarding educational experience for you.

You may contact your teaching assistant in 245 McGowan or by email at ifferbean@yahoo.com

Office hours for the teaching assistant will be posted.

Tentative Course Schedule

Date	Topic	Reading Assignment
Jan. 7	Introduction, The History of Immunology
9	General Aspects of the Immune Response	Chap. 1
10	Laboratory: No Lab This Week
11	Cells of the Immune System	Chap. 1
14	Histology of the Immune System	Chap. 1
16	Adaptive Humoral Responses, Complement	Chap. 2
17	Laboratory-Hemocytometer and Morphology
18	Inflammation and Cell Traffic	Chap. 2
21	Antigens and Antigen Recognition by B Cells	Chap. 3
23	Antigen Recognition by T Cells	Chap. 3
24	Laboratory-Computers, meet in SAC 240
25	Generation of Antigen Receptors	Chap. 4
28	Generation of Diversity
30	Antigen presentation and the MHC	Chap. 5
31	Laboratory-Ouchterlony and Radial Immunodiffusion
Feb. 1	Exam I
4	Non Adaptive Receptors, NK Cells
6	Cell Signaling I	Chap.6
7	Laboratory- Western Blot I
8	Cell Signaling II	Chap. 6
11	Development of Immune Cells, B Cells	Chap. 7
13	Development of Immune Cells, B Cells	Chap. 7
14	Laboratory-Western Blot II
15	Development of Immune Cells, T Cells	Chap. 7
18	Development of Immune Cells, T Cells	Chap. 7
20	Adaptive Humoral Immune Responses	Chap. 9
21	Laboratory-ELISA
22	Exam II
25	Adaptive Cellular Immune Responses	Chap. 8
27	Adaptive Cellular Immune Responses	Chap. 8
28	Laboratory-Clinical Immunoblot
Mar. 1	Responses to Infection	Chap. 10
4	Immunodeficiency	Chap. 11
6	Hypersensitivity Types I and II	Chap. 12
7	Laboratory- Graduate Student Presentations and Review Session
8	Hypersensitivity Types III and IV	Chap. 12
11	Autoimmunity	Chap. 13
13	Vaccination	Chap. 14
14	Laboratory Exam
15	Review Session